COLLISION-INDUCED DISSOCIATION STUDY OF ANTIMICROBIAL PEPTIDE DENDRIMERS

摘要

Peptide dendrimers are non-natural branched peptides with multibranched topologies that exhibit interesting anti-microbial properties [1]. In particular, dendritic architectures composed of lysine (K) and leucine (L) were demonstrated to be active against a broad panel of multidrug-resistant pathogens [2]. The renowned efficiency of CID for MS/MS sequencing of linear peptides was evaluated for structural characterization of a KL peptide dendrimer.