SELF-ASSEMBLED BINUCLEAR CU(II)?HISTIDINE COMPLEX FOR ABSOLUTE CONFIGURATION AND ENANTIOMERIC EXCESS DETERMINATION OF NAPROXEN BY TANDEM MASS SPECTROMETRY

摘要

Naproxen is one of the most consumed nonsteroidal anti-inflammatory drugs and marketed as S-naproxen since its R-enantiomer is hepatotoxic[1]. Developments of efficient and reliable methods for chiral differentiation and quantification of naproxen are thus essential [2].