MONITORING OF THERAPEUTIC DOSES OF ANTIPSYCHOTIC DRUGS IN SALIVA AND SERUM SAMPLES WITH THE USE OF SOLID-PHASE MICROEXTRACTION TECHNIQUE

摘要

The analysis of biological fluids to directly control the psychoactive substances is especially important in patients vulnerable to drug overdosing, e.g. pediatric and geriatric patients [1]. To provide fast and reliable information about the drug concentration, solid-phase microextraction (SPME) is introduced as a highthroughput sample preparation technique that facilitates accurate quantitation of the level of drugs in biological matrices [2,3].