THE MANAGEMENT OF HAEMOGLOBIN INTERFERENCE FOR THE MALDI-MSI ANALYSIS OF INVIVO THYROID BIOPSIES

机译：血红蛋白干扰对Invivo甲状腺活组织检查的MALDI-MSI分析

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Fine Needle Aspiration biopsy (FNAB) is the gold standard exam to determine the malignant nature of thyroid nodules[1]. Contamination of FNAB samples with red blood cells is problematic for proteomics analysis, given that large amounts of haemoglobin (Hb) suppress other protein signals[2]. Hence, it is paramount to standardise the sample preparation of ex-vivo and in-vivo thyroid FNABs for proteomic MALDI-MSI analysis, in order to minimise Hb interference.

机译：细针吸入活检（Fnab）是金标准检查，以确定甲状腺结节的恶性性质[1]。鉴于大量血红蛋白（Hb）抑制其他蛋白质信号[2]，蛋白质组学分析对FNAB样品的污染是有问题的。抑制其他蛋白质信号[2]。因此，为了使HB干扰最小化，可以将Ex-Vivo和体内甲状腺FNAB的样品制备标准化为蛋白质组学Maldi-MSI分析至关重要。

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《International Mass Spectrometry Conference》|2018年|p628-1245|共2页
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Isabella Piga; Giulia Capitoli; Vanna Denti; Silvia Tettamanti; Stefania Galimberti; Fulvio Magni; Fabio Pagni;
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中图分类分析化学;
关键词
Fine needle aspiration; thyroid lesion; haemoglobin interference; MALDI-MSI proteomics; thin prep;

机译：细针抱负;甲状腺病变;血红蛋白干扰;MALDI-MSI蛋白质组学;薄准备;

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专利

1. The management of haemoglobin interference for the MALDI-MSI proteomics analysis of thyroid fine needle aspiration biopsies [J] . Piga Isabella, Capitoli Giulia, Denti Vanna, Analytical and bioanalytical chemistry . 2019,第20期

机译：血红蛋白干扰对甲状腺微针吸附活检的MALDI-MSI蛋白质组学分析的影响
2. Feasibility Study for the MALDI-MSI Analysis of Thyroid Fine Needle Aspiration Biopsies: Evaluating the Morphological and Proteomic Stability Over Time [J] . Piga Isabella, Capitoli Giulia, Tettamanti Silvia, Proteomics. Clinical applications . 2019,第1期

机译：甲状腺微针吸附活检的MALDI-MSI分析的可行性研究：评估形态学和蛋白质组学稳定性随时间的评价
3. Role of fine-needle aspiration biopsy and frozen section analysis in the surgical management of thyroid tumors. [J] . Brooks AD, Shaha AR, DuMornay W, Annals of surgical oncology . 2001,第2期

机译：细针穿刺活检和冰冻切片分析在甲状腺肿瘤手术治疗中的作用。
4. THE MANAGEMENT OF HAEMOGLOBIN INTERFERENCE FOR THE MALDI-MSI ANALYSIS OF INVIVO THYROID BIOPSIES [C] . Isabella Piga, Giulia Capitoli, Vanna Denti, International Mass Spectrometry Conference . 2018

机译：血红蛋白干扰对Invivo甲状腺活组织检查的MALDI-MSI分析
5. Development of matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) for plant metabolite analysis [D] . Korte, Andrew R. 2014

机译：用于植物代谢物分析的基质辅助激光解吸电离质谱成像（MALDI-MSI）的开发
6. MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules [O] . Giulia Capitoli, Isabella Piga, Stefania Galimberti, 2019

机译：MALDI-MSI作为细胞病理学的辅助诊断工具：甲状腺结节表征的初步研究
7. MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules [O] . 2019

机译：MALDI-MSI作为细胞病变的互补诊断工具：甲状腺结节表征的试验研究

THE MANAGEMENT OF HAEMOGLOBIN INTERFERENCE FOR THE MALDI-MSI ANALYSIS OF INVIVO THYROID BIOPSIES

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