Improvements of TOS-SIMS mass spectrometry imaging: high spatial resolution combined with high mass resolution and high sensitivity for relative quantification

摘要

Delayed extraction and 3D-imaging using massive argon cluster allows increasing mass resolution and sensitivity both at least by a factor of 10. A repeatability of TOF-SIMS analysis better than 10% allows relative quantification of lipid species on tissue sections in two different states (healthy versus diseased samples ...).