Historical amphetamines are still here. Development of a reliable turbulent flow LC-MS/MS assay for following intoxication admitted in intensive care unit

摘要

An automated LC-MS/MS method has been developed for quantitation of amphetamines in human plasma using turbulent flow chromatography and detection by mass spectrometry (TFC-LC-MS/MS). This method is suitable and is routinely used for the analysis of toxicological samples and is applied for intoxication monitoring in patients admitted in Intensive Care unit. This LC-MS/MS method is robust reliable, and suitable for use as a confirmation assay in the simultaneous urine drug testing and quantification of historical amphetamines.