The power of ion mobility-mass spectrometry for increased selectivity in food analysis: 'a new beginning for collision cross section'

摘要

Nowadays, full scan mass spectrometry is an accessible technology. On one hand, significant improvements in assay performance are occurring rapidly in this instrumental areas e.g. Time-of-Flight analysers (ToF), have in addition to unlimited m/z range, very high sensitivity, increased mass accuracy and acquisition speed, high percentage of ion transmission but also ease of instrument set-up. On the other hand, laboratories have to perform and report under time-constrained conditions, sample treatment has become more generic with a concomitant increase in the complexity of full mass spectra. Consequently, data interpretation is becoming more complex. Ion mobility is known to be a powerful analytical tool for the separation of complex samples and have been extensively used for characterization purposes. Here, we propose to apply this technique to a whole new domain by using Collision Cross Section values as an additional identification parameter with high-resolution mass spectrometry methods.