Biotransformation of Terpenoid Lactones with the p-Menthane System

摘要

Microbial hydroxylation of non-activated carbon atom is a very valuable method of functionalization of organic molecules [1, 2]. Here we present the results of microbial transformations of γ -bicyclic lactones with the p-menthane system (1). Several biocatalysts were screened to check their ability to transform compounds studied. Three of them (Absidia cylindrospora, Absidia glauca and Syncephalastrum racemosum) were found the most effective biocatalysts. They transformed the racemic substrate (1) into the corresponding optically active hydroxylactones (2, 3, 4, 5). The hydroxylactones 5 was isolated only from product mixture obtained from biotransformation in S. racemosum cultures.