Stereoselective synthesis of peptidomimetics with PPII-helix conformation for the selective modulation of protein-protein interactions

摘要

Proline-rich-motifs-binding-domains (PRD) are promising therapeutical targets, thus the development of small molecules, which interact with those PRDs, may lead to new drugs. We have recently started a project aiming at the synthesis of peptidomimetics to selectively modulate PRD-dependent biological processes.