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SELECTIVE MODULATION OF PROTEIN-PROTEIN INTERACTIONS
SELECTIVE MODULATION OF PROTEIN-PROTEIN INTERACTIONS
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机译:蛋白质-蛋白质相互作用的选择性调节
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摘要
The present disclosure provides methods to identify peptides and small molecule moieties that are able to modulate protein-protein interactions (PPIs). Some moieties can disrupt specific PPIs within a complex, or disrupt variant-specific PPIs. Some moieties can alternatively bridge between two proteins in a protein-specific or a variant-specific manner. The methods described enable generation of compounds able to modulate PPI networks within cells with implications for drug development for pathological conditions.
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