Catalytic Asymmetric Multicomponent Reductive/Alkylative Aldol Reactions with Allenic Esters and Unactivated Ketones(Abstracts)

摘要

Development of asymmetric reactions that assemble three or more reagents in one-pot under the promotion and streo-control by an asymmetric catalyst (catalytic asymmetric multicomponent reaction: CAMCR) is great challenge today. Specifically, CAMCR that can construct chiral tetrasubstituted carbons has just begun to be explored. These reactions can rapidly increase the molecular complexity from relatively simple reactants, and produce structurally diverse array of chiral building blocks containing tetrasubsituted carbons, which are inaccessible by known reactions. We will present a copper-catalyzed asymmetric multicomponent reductive/alkylative aldol reaction that assembles ketones, allenic esters, and pinacolborane/dialkylzincs.