Investigating the Mechanism of Palladium Catalysed Isomerisations(Abstracts)

摘要

In 2001, Lloyd-Jones et al. reported the highly efficient and regioselective cycloisomerisation of dimethyl diallyl malonate 1, using (~tBuCN)2PdCl2 as the pre-catalyst, to form cyclopentene 2 (Scheme 1). To elucidate the mechanism of the reaction, extensive studies have been carried out: kinetics, isotopic labelling (~2H, ~(13)C), the effect of aryl substituted analogues of 1 on the regioselectivity and the influence of various alkenes on the reactivity.