Multidisciplinary Approach to Genome-Wide Association Study for Heart Failure Based on the Different Ethnicity - An overview of the bioinformatics and a new concept of BWAS -

摘要

Preface: Heart failure (HF), a serious syndrome with diverse ethnicity and complicated etiology, is one of the leadingcauses of death. A part is heritable, though its underlying factors still remain elusive. GWAS (genome-wide associationstudy) is promising for identifying the causative genes, directly or indirectly related genes as well as modifiergenes that aggravate or ameliorate the clinical process to the advanced phase (1). This overview mainly focused ouron-going HF-GWAS trial for the pathogenesis and/or progression of HF at the worldwide and whole genome level,irrespective of the variable (genetic, infectious, ischemic, degenerative, hormonal or metabolic) causes common-in orspecific-to different ethnicity, without missing biologically significant genes. We addressed a novel concept ofBigenome (nuclear and mitochondrial)-Wide Association Study (BWAS) to solve the complexity in the progressionmechanism of HF and to provide a beneficial therapeutics.