Impairment in left ventricular mechanics in patients with obstructive sleep apnea

摘要

Obstructive sleep apnea (OSA) may predispose to left ventricular (LV) remodelling, hypertrophy andheart failure. Our aim was to determine relationships between OSA and myocardial mechanics reflected bymyocardial deformation and LV diastolic function. In twenty patients with severe OSA [47.9 3.6 years; apneahypopneaindex (AHI) 72.4 6.0 events/h; lowest SaO2 62.0 5.6%] and 20 control subjects [40.7 3.3 years; AHI7.4 1.0 events/hour; lowest SaO2 88.3 1.4%], no differences were observed between control subjects andpatients in LV ejection fraction, LV mass and LV mass index (60.8±1.6 vs 59.2±1.5%, p=0.467; 184.0±7.5 vs198.0±11.5 g, p=0.310; 89.9±2.6 vs 89.4±5.0 g/m2, p=0.929, respectively). Compared to control subjects,patients with OSA had significantly reduced GLS (-17.3±0.8 vs -14.4±0.7%, p=0.009), and higher A wave inassociation with reduced E/A ratio (59.2±2.1 vs 70.7±3.4 cm/s, p=0.007; 1.28± 0.08 vs 0.97±0.07, p=0.006,respectively). Our results suggest that OSA is related to impairments in LV relaxation and contractility.