Magnetic hyperthermia (MH) and thetmoablation therapies are amongst the non-invasive approach in the treatment of cancer. Platelet gamma-Fe_2O_3 and Fe_3O_4(DINP) nanoparticles were synthesized in a solid phase reduction of platelet a-FeOOH particles using hydrogen gas and were developed as a candidate for application in MH involving hysteresis-loss heating [1]. In this process, the SiO_2 coating used to prevent sintering of particles were found to cause a decrease in magnetization. In the ensuing investigation, we proposed using tetraethylene glycol as the reducing agent to obtain magnetite nanoparticles in a liquid phase reduction [2]. This process is advantageous as SiO_2 coating is not required for a liquid phase process. However, the morphology evolution of the platelet Fe_3O_4 nanoparticles obtained from this pathway remains unclear, making it difficult to control the particle size, shape and distribution, which are crucial for the application in MH Here, by varying the synthesis reaction time, we aim to study the morphology evolution to understand further the formation of magnetite nanoparticles in the liquid phase reduction.
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