Synthesis and Optimization of Methods for the Production of Magnetite Nanoparticles with Different Sizes and Morphology for Biological Application

摘要

Herein we report on the synthesis, optimization of the synthetic procedure, functionalization, and characterization of cubic and spherical superparamagnetic magnetite nanoparticles. Spherical nanoparticles (16 ± 2 nm) were synthesized using oleylamine and oleic acid, and cubic （20 ± 2，5 ± 0.5 nm） nanoparticles were synthesized with oleic acid and small amounts of oleylamine. Covalent modification of the nanoparticles was carried out using heterobifunctional PEG with aminopropyltriethoxysilane and N-hydroxysuccin-imide ester moieties. This modification makes both water emulsion stability and further modification of the nanoparticles with cytotoxic drugs possible.