Quantification of quorum sensing molecules and their interaction with polymyxin-B hemoperfusion in human plasma by LC-HRMS

摘要

Both HRMS and NL or PI MS/MS methods show to be fast and selective for the rapid quantification of bacterial small molecules in biological fluids. Preliminary experimental data indicate that the method is suitable for the analysis of biofluids and evidence the ability of PMX-B bound membrane to interact with AHL QS molecules.