Conformational characterization of Nerve growth factor-β and the impact of its regulatory pro-part domain

摘要

proNGF contains both O-linked and N-linked glycans in the pro-part of the protein. The pro-part of proNGF contains one region with local higher-order structure, which interacts with the mature part of the protein. The presented results are valuable in understanding the diverse biological effects of NGF and proNGF on neurons, and can be used to develop drugs targeting the proNGF-sortilin interaction.