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Proteomics Analysis of Aged Healthy Human White Blood Cells

机译:老年健康人白细胞的蛋白质组学分析

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摘要

Chronic inflammation has been proposed to be involved in aging-related physiological changes. In this pilot study, we characterized the proteomes of whole PBMC, B and T cell subpopulation, and innate immune cells from 3 healthy subjects over 70 years old. We find evidence suggesting a core PBMC proteome, and several cell-type specific markers. Correlation analysis also shows various levels of commonality in the proteomes of different subjects, with monocytes showing high commonality and B cells much lower.
机译:已经提出慢性炎症参与衰老相关的生理变化。在这项试验研究中,我们以70岁以上的37岁以上的3个健康受试者的全部PBMC,B和T细胞群的蛋白质蛋白质组成。我们发现证据表明核心PBMC蛋白质组,以及几种细胞类型特异性标记。相关分析还显示不同受试者蛋白质蛋白质中的各种水平的共性,单核细胞显示出高常见的和B细胞。

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