目的 探讨白细胞介素18(IL-18)、白细胞介素10 (IL-10)在老年亚健康状态发生发展中的作用及相互关系.方法 应用酶联免疫吸附法测定45例亚健康状态老年人(≥60岁)血浆IL-18和血清IL-10水平,以42例亚健康状态老年前期(50 ～59岁)和30例健康老年人(≥60岁)作比较,分析它们之间的关系.结果 亚健康状态老年人血浆IL-18水平显著高于健康老年人(P＜0.01),以及亚健康老年前期组(P＜0.05),血清IL-10水平则显著低于对照组(P＜0.01)和老年前期组(P＜0.05)；血浆IL-18水平与血清IL-10水平之间呈负相关(r=-0.882,P＜0.01).结论IL-18和IL-10可能共同构成一局部网络,并可能参与亚健康状态的发生发展过程.%Objective To study the changes of plasma interleukin 18(IL-18) and serum interleukin 10(IL-10) in the elderly people with sub-health (SH) and the clinical significance. Methods The plasma level of IL-18 and serum level of IL-10 in 45 elderly people with SH were measured by enzyme linked immune sandwich assay (ELISA) , 42 prevenient elderly people with SH and 30 healthy elderly persons( HEP) were enrolled as control. The relationships of IL-18 and IL-10 with SH were analyzed. Results The level of IL-18 in elderly people with SH was significantly higher than that in HEP(P<0.01) , and that in prevenient elderly people with SH(P<0.05). The level of IL-10 in elderly people with SH was significantly lower than that in HEP(P < 0. 01) , and that in prevenient elderly people with SH (P < 0. 05). The level of IL-18 in elderly people with SH was negatively correlated with the level of IL-10( r = -0. 882, P <0. 01). Conclusions The cytokine network constructed by IL-18 and IL-10 may be involved in the pathogenesis and development of subhealth.
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