Open-Access LC/MS/MS Platform for Rapid Bioanalysis in Drug Discovery

摘要

There are numerous types of in vitro ADME assays conducted in lead optimization phases of small molecule drug discovery. Nearly all of these assays use LC/MS/MS for bioanalytical quantification. The myriad of assays and formats can make communication around sample handoff between bioassay and bioanalytical scientist time consuming and prone to error. With the additional advancements in automation described here we have been able to improve productivity associated with the sample analysis. The open-access approach allows both bioanalytical and bioassay scientist to treat ADDA-OAR workstation as an appliance and/or plate-reader style measurement device and proficiently run routine samples. This approach has further shown resource efficiency as it allows bioanalytical personnel time to develop difficult or specialty LC/MS/MS methods, thereby accelerating project progression overall.