Tissue-Engineered Long Term Hepatocyte Co-culture Model And Data Independent Mass Spectrometry Acquisition To Identify Multi Generation Metabolites

摘要

Multispecies HepatoPac provides a long-term bioengineered liver model to run in vitro species comparison studies with excellent metabolic coverage correlated to drug clearance upon incubation with physiologically-relevant compound concentrations. The appearance of major human metabolites of Tolbutamide and Ziprasidone in human hepatocytes and across multiple pre-clinical species was consistently documented.