IMPURITY CHARACTERISATION OF THE FUNGICIDE FLUTRIAFOL USING LIQUID CHROMATOGRAPHY AND TIME OF FLIGHT MS DETECTION TO AID PESTICIDE PRODUCT REGISTRATION

摘要

Minor components present in technical grade flutriafol were detected at 220 nm. Unidentified components were characterised using UPLC coupled with ToF MS~E and UNIFI Scientific Information System. Two components were tentatively identified as isomers of the active ingredient, a third unknown component was also observed. Using the elucidation toolset within UNIFI, the unknown component was found to have structural features that were common to the flutriafol. Based on the elemental composition of the fragments, knowledge of the synthetic route and the structure of the active ingredient, a structure for the unknown component having m/z 314.1303 was tentatively proposed. This tentative structure is in agreement with all of the data that is currently available. Future impurity isolation studies will allow for the definitive determination of the structures of these impurities.