Real-time Breath Monitoring of Valproic Acid by Mass Spectrometry with Low Temperature Plasma Ionization Source

摘要

Low temperature plasma Ionization mass spectrometry is shown to allow real time analysis of Valproic acid in exhaled breath by the measurement of a metabolite γ-Valprolactone, and can be used for quantification of γ-Valprolactone concentration to monitor VPA during epilepsy management.