Development of an Instant Glycan Labeling Dye for High Throughput Analysis by Mass Spectrometry

摘要

1 IMS has the highest fluorescence response of any glycan label tested 2 IMS shows high MS response, superior to Procainamide, and comparable to Competitor X 3 IMS rapid LC methods separate Man5 from G1 for mAb screening 4 New 5-minute deglycosylation method using MS friendly denaturant enables both screening and in-depth characterization on N-glycans using a single workflow