Comparative Proteomic and Metabolomic Studies of Pulmonary Nanoparticle Exposure in Rats using Liquid Chromatography Tandem Mass Spectrometry

摘要

Observed expected up regulation of Production of Nitric Oxide and Reactive Oxygen Species in Macrophages pathway. Observed unexpected down regulation of Acute Phase Response Signaling and LXR/RXR Activation pathways: 1. Studies have shown an up regulation in these pathways from differentially expressed genes in mice lung tissue.