A Common Data Analysis Pipeline for the Clinical Proteomics Tumor Analysis Consortium (CPTAC)

摘要

The National Cancer Institute formed a Clinical Proteomic Tumor Analysis Consortium (CPTAC) in 2011, a follow-on to the original CPTAC program (2006-2010) focused on technology assessment, to facilitate the identification of cancer-specific protein biomarkers. The consortium has eight institutions as lead centers, with approximately thirty collaborating groups (Figure 1.) The idea behind the program was to leverage genome information available through NCI's Cancer Genome Atlas program (TCGA) to provide corroborating protein-level evidence for various genomic aberrations as well as to identify PTMs. The purpose of the common data analysis pipeline (CDAP) is to remove the variability introduced by disparate data analysis tools and to provide a common set of results for public consumption.