Streamlined Method Development for PK Analysis Utilizing Robotic Sample Preparation and Ultra-fast SPE-MS/MS Using a Newly Developed Triple Quadrupole MS

摘要

Streamlined method development was achieved in 20 minutes using an Agilent RapidFire 365 HTMS system together with an Agilent 6470 QQQ MS for the analysis of small molecule pharmaceuticals in a precipitated plasma matrix. Analytical robustness of an Agilent 6470 QQQ MS system was demonstrated by achieving peak area ratio RSD [%] values of 8.3% or better over ～5 days and 10,000 sample injections.