The effect of chitosan nanoparticle to hepatic cells -Is chitosan nanoparticle an enhancer of AKT1/mTOR pathway?

摘要

In this study, CCL-13 and HepG2 cells were served as cell models for the uptake of chitosan nanoparticles. To evaluate early responses of CCL-13 and HepG2 cells to chitosan nanoparticles, a mass spectrometry-based profiling system was adopted for assessing characteristic proteins that were expressed due to the interactions of CCL-13 and HepG2 cells with chitosan nanoparticles. Through the investigation, various proteins that influence the early responses of CCL-13 and HepG2 cells on chitosan nanoparticle were found, and, as we know, some of them have not been reported in the study of cell-nanoparticle interactions.