A Rapid and Sensitive Solid Liquid Extraction Method to Eliminate The Matrix Effects of Liquid Chromatograpy-tandem Mass Spectrometry for The Determination of Levonorgestrel in Plasma

摘要

1.Compared to LLE,SLE can eliminate phospholipids much more significantly according to figure 3 ad figure 4 above, so a more sensitive and accurate method was se tup. In this method, the recoveries of spiked samples at the level of 5 ng/mL and 10 ng/mL were found in a range from 91.82% to 101.74% and 92.13% to 99.46%, while relative standard deviations of the recoveries (n = 5) were from 3.02% to 4.10%. 2.The procedures of SLE contains only two steps: sample loading and elution, which cause a rapid and easy operation for the assay in DMPK research.