Investigation into biomarkers of antidepressant response in a mouse model of depression using isobaric labels (tandem mass tags) and 2DE

摘要

Using complementary proteomic approaches both models clearly high-lighted the many strain differences in the data sets. More subtle differences pertaining to treatment are being further explored in these proteomic data sets along with protein identification of 2DE spots that best explain the experimental factors. The biological significance of these data, in-line with the aims of GENDEP, will be further examined through the integration between these and other proteomic and transcriptomic data sets available across GENDEP.