Performance enhancement for a hybrid 1 T permanent magnet ESI-FTICR mass spectrometer using multiple frequency detection

摘要

Detection of the FTICR signals at multiple of reduced cyclotron frequency using multi-electrode detection is equivalent to the corresponding increase in effective magnetic field and results in the increase in FTICR instrument's resolving power [4,5]. Due to the space charge effects and the corresponding increase in the contribution of inhomogeneous factors into the line broadening (mainly, frequency drift during detection) for the signals at multiple frequency, the mass measurement accuracy may respectively deteriorate. Multiple-frequency detection technique may be useful in high-throughput applications of FTICR mass spectrometry, including high magnetic field instruments because it allows corresponding reduction in time-domain acquisition period without a loss of resolving power.