MALDI-produced Ions analyzed by Higher Energy Collisional Dissociation (HCD) using a Linear Ion Trap - Orbitrap Mass Analyzer

摘要

HCD - proven to provide high quality MS/MS data for ESIproduced ion - is able to provide high quality data also of singly charged ions produced by MALDI. For singly charged ions complete b-, and y-ion series can be found. HCD supports isobaric labeling strategies. Internal fragments can be assigned unambiguously because of accurate mass and high mass resolution provided by Orbitrap detection. Small molecules and carbohydrates can be structurally elucidated by HCD.