High-Field Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Ultrahigh Mass Resolving Power, Mass Accuracy, Speed, and Dynamic Range

摘要

At least nine performance parameters scale linearly or quadratically with magnetic field strength in Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry (Rapid Commun. Mass Spectrom. 1996, 10, 1819-1823), including mass resolving power, mass accuracy, measurement speed, and dynamic range. In this work, we describe the current state-of-the-art at 9.4 and 14.5 tesla and efforts to achieve 21 tesla in the future. In addition to field strength, magnet characteristics such as field homogeneity, temporal stability, stray field, size, and cryogenic performance are critical. Further, technological advances such as hybrid quadrupole FT-ICR, automatic gain control (AGC), and rapid and efficient MS/MS, and automated data reduction are at least as important as magnetic field strength and quality.