The effect of chiral ionic liquids on resolution of racemates by enantioselective crystallization was studied. A chiral solvent is assumed to be able to create some weak interactions between the solvent and the substrate species forming diastereomeric complexes. This could eventually lead to differences in solubilities or differences in the rate of crystallization of both enantiomers, which can be exploited for resolution purposes. Since their structured nature might be advantageous for chiral recognition, in this work special emphasis is directed to the use of chiral ionic liquids in enantioselective crystallization. First results on the ternary solubility phase diagram of N-methylephedrine as a chiral racemate to be resolved and the chiral ionic liquid (S)-2-methoxycarbonyl)pyrrolidinium bis(trifluoromethylsuifonyl)amide will be shown. Further, analytical issues in presence of the chiral ionic liquid will be addressed.
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