New crystalline forms of Racemic and Homochiral Atenolol with Cinnamic Acid

摘要

R- and S-Atenolol crystallize as a solid solution from which it is difficult to separate the enantiomers. Both RS- and R-Atenolol form a new crystalline phase in the presence of sufficient amounts of cinnamic acid in ethanol. The XRPD patterns of RS-Atenolol/Cinnamic acid and R-Atenolol/Cinnamic acid acid show distinct features indicating that these new crystalline phases have distinct crystalline structures. The solvent mediated transformation indicates considerable morphological differences between the two new crystalline phases. It is possible that the Atenolol solid solution is transformed into a racemic/homochiral crystal system via adduction with cinnamic acid. Other co-builders might change it to a conglomerate system.