FORMULATION OF A CONTROLLED RELEASE CHEMOTHERAPEUTICAL SYSTEM BY THE ATOMIZED RAPID INJECTION SOLVENT EXTRACTION (ARISE) PROCESS

摘要

Dense gas anti-solvent precipitation processes have been studied extensively over the past two decades for the development of novel drug formulations. Their advantages include tunable fluid properties and a reduced use of toxic organic solvents. The Atomized Rapid Injection Solvent Extraction (ARISE) process is a recently developed dense gas anti-solvent process. The use of capillary nozzles, required by most dense gas anti-solvent processes, is eliminated and process operation is greatly simplified. In this study, the feasibility of using the ARISE process for the co-precipitation of the hydrophilic anticancer drug 5-fluorouracil with poly L-lactic acid was demonstrated. The effects of the processing conditions on particle morphology, encapsulation efficiency and drug loading were studied.