Motility and Allergy

摘要

Food allergy occurs in 6-8% of children and 1-2% of adults and is permanently increasing throughout the world [1, 2]. Most of the adverse reactions to food are immune-mediated reactions, and food antigens may cause IgE and non-IgE immune responses. Of the numerous symptoms of food allergy, at least in the early stages, gastrointestinal disorders, from food protein-induced enterocolitis to constipation, are of paramount importance and are often associated with proctitis. Celiac disease is a specific food protein-induced enteropathy, but eosinophilic gastroenteritis and esophagitis are combined IgE and T-cell-mediated disorders observed in food allergy. Most of these gut inflammatory responses are associated with diarrhea resulting from both secretory and motility disorders and constipation is only observed in IgE sensitization to cow's milk [3]. Experimental data suggest that a type-1 IgE and a mast cell-dependent hypersensitivity response, particularly for motility disorders, mediate the majority of this acute food antigen-induced allergic reaction in the gastrointestinal tract.