Aetiological structure of chronic liver disease in children in Moscow

摘要

Investigation of the aetiological structure and natural history of chronic liver disease is a very real problem in modern hepatology.Aim: To determine the aetiological structure and severity of chronic liver disease in patients of the Paediatric Gastroenterology Department in Moscow in 2000.Methods: All patients were evaluated using blood chemistry, serology, poly-merase chain reaction, ultrasonography and liver biopsy.Results: 172 patients were evaluated: chronic hepatitis B was revealed in 48 (27.9%) (including 1 patient with cirrhosis); chronic hepatitis C in 32 (18.6%) (including 1 with cirrhosis); chronic hepatitis B+C in 5 (2.9%); chronic hepatitis D in 6 (3.5%) (including 4 with cirrhosis); autoimmune hepatitis in 14 (8.1%) (8 with cirrhosis); Wilson disease in 11 (6.4%) (4 with cirrhosis); glycogen-storage disease in 22 (12.8%); drug-induced hepatitis in 2 (1.2%); cryptogenic liver disease in 8 (4.7%); and other hepatobiliary diseases in 24 (14%).