T-wave alternans (TWA) has been associated with ventricular arrhythmias, and some of them are non-stationary, short-episode events (less than 128 beats). A specific time-domain algorithm for isolating T-wave alternans from ECG signals during exercise was developed. The purpose of this study was to test the hypothesis that the time-domain TWA algorithm can accurately quantify exercise TWA patterns, either long or short in duration, and evaluate the TWA measurement difference between time-domain and frequency-domain TWA methods.
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