(Background)The Bmgada syndrome is known to have a high incidence of sudden cardiac death. The effective treatment is ICD and there is no reliable treatment with drugs. (Purpose)To investigate the effect in preventing ventricular fibrillation (VF) inducibility by programmed electrical stimulation (PES) in symptomatic or asymptomatic patients with the Brugada syndrome after oral administration of quinidine. (Methods)PES was performed in 9 patients(all men,mean age 53.9+-13.0 years) who showed characterstic Brugada type ECG.VF was inducible in all of them during baseline PES. After quinidine administration(466.7+-158.1mg/day), PES was performed again.The stimulation protocol included 2 basic cycle length (400ms,600ms) and up to 3 premature stimuli using two stimulation sites (right ventricular apex and right ventricular outflow tract). (Results)After oral administration of quinidine,VF was not induced in 5 of 9 patients. In 3 of the remaining 4 patients whom VF was still induced, more number of premature stimuli were needed than during baseline. 2 patients who received ICD implantation had multiple episodes of VF. Quinidine was effective in suppressing VF inducibility during PES for the one but not for the other. Clinically, both patients were asymptomatic during the follow-up periods of 20 months under quinidine treatment. (Conclusion) Quinidine has a possibility to prevent VF in Brugada syndrome.
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