HOW DOES SODIUM CHANNEL DYSFUNCTION RELATE T REPOLARIZATION ABNORMALITIES IN THE RIGHT VENTRICULAR OUTFLOW TRACT IN BRUGADA SYNDROME?

摘要

Backgrounds. Mutations in sodium gene, SCN5A, have been identified in Brugada syndrome (BS), but it is unclear how sodium channel dysfunction relates to arrhythmogenesis. Method. Eighty-seven-leads body surface ECG were recorded under baseline condition, during isoproterenol (ISP; 0.02ug/kg/min) infusion and after pilsicainide (PLS;