Using crystallization technology improves the after-processing properties of active pharmaceutical ingredients

摘要

Manufacturing of pharmaceutical solid dosage forms involves several processes including flow through sieving, pouring, blending, die-filling and compaction. The powder properties like flowability and bulk density, which are to some extent inter-related, are highly sensitive to those processes, and affect the quality of the final product. Many active pharmaceutical ingredients exhibit deficient bulk powder properties, such as poor flow and high propensity for adhesion/cohesion due to their small particle size. Small particles have a relatively high specific surface area, where van der waals and electrostatic forces dominate over gravitational force, causing high degrees of adhesion to surfaces and cohesion to neighboring particles. The properties of larger particles are more important than their agglomerate shapes, and it tend to roll over one another when a shear stress is present and exhibit higher flowability.