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Cluttering delivery vehicles for the pharmaceutical and cosmetic active ingredients that are poorly soluble in water and to suppress crystallization of pharmaceutically active ingredients

机译:药物和化妆品活性成分的杂物运输工具,难溶于水并抑制药物活性成分的结晶

摘要

1. A pharmaceutical or cosmetic composition comprising: - a substantially poorly water-soluble pharmaceutical active ingredient or a cosmetic active ingredient; u folate nanoporous material, wherein the active pharmaceutical ingredient is enclosed within a nanoporous chastits.2 channels. A composition according to claim 1, characterized in that the substantially poorly water-soluble pharmaceutical active ingredient consists of one or more compounds selected from the group of fungicides, analgesics, cholesterol absorption inhibitors, antipyretics, anti-inflammatories, decongestants, antihistamines, anti-retroviral and anti-tumor drugs .3. A composition according to claim 1, characterized in that the said cosmetic active ingredient substantially poorly soluble in water consisting of one or more compounds selected from the group consisting of fat-soluble vitamins and provitamins and vitamins stabilized and stabilized provitaminy.4. A composition according to claim 1, characterized in that the pharmaceutical or cosmetic active ingredient is poorly soluble in water is present in an amount from about 0.1 wt.% to 90 wt.%, preferably in the range of 15-55 wt.% of the total weight of the nanoporous material .5. A composition according to claim 1, characterized in that said poorly water-soluble compounds are the active ingredients with a solubility of 10 g / l, preferably 1 g / l, in water at a temperature of 25 ° C or have a distribution constant greater than 2, or violate at least one of the five Lipinski.6 Regulation. A composition according to claim 1, characterized in that the particle size of these nanoporous materials sost
机译:1.一种药物或化妆品组合物,其包含:-基本上不溶于水的药物活性成分或化妆品活性成分;和叶酸纳米孔材料,其中活性药物成分被包封在纳米孔chasits.2通道内。 2.根据权利要求1所述的组合物,其特征在于,所述水溶性差的药物活性成分由选自以下的一种或多种化合物组成:杀真菌剂,止痛剂,胆固醇吸收抑制剂,退热剂,抗炎药,减充血药,抗组胺药,抗逆转录病毒和抗肿瘤药物.3。 2.根据权利要求1的组合物,其特征在于所述化妆品活性成分基本上不易溶于水,所述水由一种或多种选自脂溶性维生素和维生素原以及稳定和稳定的维生素的化合物组成。4。 2.根据权利要求1所述的组合物,其特征在于,所述药物或化妆品活性成分在水中难溶,其存在量为约0.1重量%至90重量%,优选为15-55重量%。纳米多孔材料的总重量.5。 2.根据权利要求1所述的组合物,其特征在于,所述水溶性差的化合物是在25℃的温度下在水中的溶解度<10g / l,优选<1g / l的活性成分。常数大于2,或违反Lipinski.5法规中的至少一项6。 2.根据权利要求1的组合物,其特征在于这些纳米多孔材料的颗粒尺寸

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