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Cluttering delivery vehicles for the pharmaceutical and cosmetic active ingredients that are poorly soluble in water and to suppress crystallization of pharmaceutically active ingredients
Cluttering delivery vehicles for the pharmaceutical and cosmetic active ingredients that are poorly soluble in water and to suppress crystallization of pharmaceutically active ingredients
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机译:药物和化妆品活性成分的杂物运输工具,难溶于水并抑制药物活性成分的结晶
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摘要
1. A pharmaceutical or cosmetic composition comprising: - a substantially poorly water-soluble pharmaceutical active ingredient or a cosmetic active ingredient; u folate nanoporous material, wherein the active pharmaceutical ingredient is enclosed within a nanoporous chastits.2 channels. A composition according to claim 1, characterized in that the substantially poorly water-soluble pharmaceutical active ingredient consists of one or more compounds selected from the group of fungicides, analgesics, cholesterol absorption inhibitors, antipyretics, anti-inflammatories, decongestants, antihistamines, anti-retroviral and anti-tumor drugs .3. A composition according to claim 1, characterized in that the said cosmetic active ingredient substantially poorly soluble in water consisting of one or more compounds selected from the group consisting of fat-soluble vitamins and provitamins and vitamins stabilized and stabilized provitaminy.4. A composition according to claim 1, characterized in that the pharmaceutical or cosmetic active ingredient is poorly soluble in water is present in an amount from about 0.1 wt.% to 90 wt.%, preferably in the range of 15-55 wt.% of the total weight of the nanoporous material .5. A composition according to claim 1, characterized in that said poorly water-soluble compounds are the active ingredients with a solubility of 10 g / l, preferably 1 g / l, in water at a temperature of 25 ° C or have a distribution constant greater than 2, or violate at least one of the five Lipinski.6 Regulation. A composition according to claim 1, characterized in that the particle size of these nanoporous materials sost
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