Beclomethasone Micronization Using Gas Antisolvent Process

摘要

Gas antisolvent process performances for micronization of beclomethasone dipropionate from ethyl alcohol solutions have been investigated. The experimental tests have been performed using a new patented nozzle for the injection of the supercritical solvent and the solution into the particle precipitation vessel. The influence of pressure, temperature, solution flow rate and solution concentration on particle size and powder yield have been investigated. The experimental tests have been performed in the pressure range 7.0-10.8 MPa and at temperatures of 40 and 50°C. The maximum powder yield was 36% and was obtained at 40°C and 8.2 MPa. Powder mean size has been evaluated by SEM image analysis. The minimum mean size of powders is of about 1μm and was obtained at 40 K and 80 bar.