DEVELOPMENT OF LIPID PARTICLES WITH SUPERCRITICAL CARBON DIOXIDE

摘要

The search for suitable carrier systems for different active substances is a major challenge for the pharmaceutical industry to overcome problems related to poorly water-soluble compounds and their bioavailability. This seek is also of great interest for the food and cosmetic industry since it possibles the incorporation of additives regardless of their hydrophobicity. In this study lipid particles loaded with ascorbic acid were produced using the PGSS concept, with carbon dioxide and GRAS lipid excipients. The particles obtained were analysed by ESEM, DSC, HPLC and single-particle-counting technique.