Susceptibility to amyloidosis is reduced in females as compared to males in several disease entities (1-3). Environmental or genetic factors may underlie this gender difference. The present study was undertaken to explore a possible lower propensity for amyloidogenesis in female mice and to elucidate hormonal associations of such a possible trend.METHODSExperimental designMale and female Swiss mice, 8 to 18 weeks old, underwent induction of amyloidosis and the presence and amount of splenic amyloid was compared in the 2 sexes. The effect of sex hormones and adrenalin was determined by co-administration of hormones with amyloid induction and comparing the amount of splenic amyloid to control mice, receiving the solvents of the hormone alone.
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