SUPEROXIDE DISMUTASE, CATALASE, GLUTATHIONE PEROXIDASE, AND GLUTOTHIONE REDUCTASE IN THE HEART OF HYPERGRAVITY-TREATED AND AGING RATS

摘要

Activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GP), and glutathione reductase (GR) were determined in the heart of young and old control and hypergravity (HG) treated male Wistar rats. Relatively small and insignificant changes were observed when comparing enzyme activities in the heart of young and old control rats, whereas HG induced significant decline of SOD and GP in the group of old rats and GR in young animals. Statistically highly significant positive correlation found for SOD and downstream acting catalase in young (r=0.72; P<0.00001) and old rats (r=0,86; P<0.00001) was preserved in HG-treated young animals as well (r=0.66; P<0.02), assuming that SOD-catalase pair could remain functionally related in both aging and HG. However, three-dimensional (3D) nonlinear plotting and cluster analysis revealed significant alterations in enzyme relations in the heart of both aging and HG-treated animals.