A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors

摘要

Anesthetics have been reported to suppress NMDA receptor function, however, mechanisms of the inhibition by anesthetics of NMDA receptors are not fully understood. Here, we report a residue in transmembrane 3 (TM3) region of the NR1 subunit of NMDA receptors, which is critical for anesthetic inhibition.