Development of microcapsules for shock wave DDS and angiogenesis using shock waves

摘要

This paper describes the trial of making microcapsules including a bubble for shock wave drag delivery systems, evaluation of their mechanical properties and angiogenesis using plane shock waves. We have proposed drug delivery systems (DDS) using shock waves. In this system, a microcapsule including a gas bubble is flown in the blood vessel, and finally broken by shock induced microjet, then drag is reached to the affected part. In this paper, the mechanism for deformation and disintegration of capsules in our previous works is reviewed, and the trials of making special microcapsules are discussed. To determine Young's modulus of capsule membrane, the membrane is deformed by the aspiration device and compared with computational result by FEM. As for angiogenesis using shock wave, the effects of shock waves under 0.4 MPa on cell growth rate is investigated. It is found that increasing rate of cell population by working shock waves is faster than the control cells.